PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19661292-0 2009 Induction of apoptosis by staurosporine involves the inhibition of expression of the major cell cycle proteins at the G(2)/m checkpoint accompanied by alterations in Erk and Akt kinase activities. Staurosporine 26-39 AKT serine/threonine kinase 1 Homo sapiens 174-177 19661292-9 2009 Treatment of U-937 cells with staurosporine at 1 microM for 24 hours, compared with 0.5 microM for 18 hours, appeared to kill the leukemic more efficiently cells and this dose and duration may specifically target p27, Erk and Akt pathways that are important for cancer cell survival and resistance to treatment. Staurosporine 30-43 AKT serine/threonine kinase 1 Homo sapiens 226-229