PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19497963-0	2009	Urokinase activates macrophage PON2 gene transcription via the PI3K/ROS/MEK/SREBP-2 signalling cascade mediated by the PDGFR-beta.	Reactive Oxygen Species	68-71	paraoxonase 2	Homo sapiens	31-35	
19497963-1	2009	AIMS: We have recently shown that urokinase plasminogen activator (uPA) increases oxidative stress (OS), cholesterol biosynthesis, and paraoxonase 2 (PON2) expression in macrophages via binding to its receptor, the uPAR.	Cholesterol	105-116	plasminogen activator, urokinase	Homo sapiens	34-65	
19497963-1	2009	AIMS: We have recently shown that urokinase plasminogen activator (uPA) increases oxidative stress (OS), cholesterol biosynthesis, and paraoxonase 2 (PON2) expression in macrophages via binding to its receptor, the uPAR.	Cholesterol	105-116	plasminogen activator, urokinase	Homo sapiens	67-70	
19497963-2	2009	Since PON2 is regulated by both OS and cholesterol content, we hypothesized that uPA elicits a cascade of signal transduction events shared by NADPH oxidase and cholesterol biosynthesis that culminates in PON2 gene expression.	Cholesterol	39-50	paraoxonase 2	Homo sapiens	6-10	
19497963-2	2009	Since PON2 is regulated by both OS and cholesterol content, we hypothesized that uPA elicits a cascade of signal transduction events shared by NADPH oxidase and cholesterol biosynthesis that culminates in PON2 gene expression.	Cholesterol	39-50	plasminogen activator, urokinase	Homo sapiens	81-84	
19497963-2	2009	Since PON2 is regulated by both OS and cholesterol content, we hypothesized that uPA elicits a cascade of signal transduction events shared by NADPH oxidase and cholesterol biosynthesis that culminates in PON2 gene expression.	Cholesterol	161-172	paraoxonase 2	Homo sapiens	6-10	
19497963-2	2009	Since PON2 is regulated by both OS and cholesterol content, we hypothesized that uPA elicits a cascade of signal transduction events shared by NADPH oxidase and cholesterol biosynthesis that culminates in PON2 gene expression.	Cholesterol	161-172	plasminogen activator, urokinase	Homo sapiens	81-84	
19497963-6	2009	Indeed, uPA upregulated PON2 expression in a sterol regulatory binding protein-2 (SREBP-2)-dependent manner, since blocking SREBP-2 maturation by 4-(2-aminoethyl)-benzenesulfonyl fluoride abolished uPA-stimulation of PON2, whereas inhibition of SREBP-2 catabolism by N-acetyl-leucyl-norleucinal had an opposite effect.	4-(2-aminoethyl)benzenesulfonylfluoride	146-187	plasminogen activator, urokinase	Homo sapiens	8-11	
19497963-6	2009	Indeed, uPA upregulated PON2 expression in a sterol regulatory binding protein-2 (SREBP-2)-dependent manner, since blocking SREBP-2 maturation by 4-(2-aminoethyl)-benzenesulfonyl fluoride abolished uPA-stimulation of PON2, whereas inhibition of SREBP-2 catabolism by N-acetyl-leucyl-norleucinal had an opposite effect.	4-(2-aminoethyl)benzenesulfonylfluoride	146-187	paraoxonase 2	Homo sapiens	24-28	
19497963-6	2009	Indeed, uPA upregulated PON2 expression in a sterol regulatory binding protein-2 (SREBP-2)-dependent manner, since blocking SREBP-2 maturation by 4-(2-aminoethyl)-benzenesulfonyl fluoride abolished uPA-stimulation of PON2, whereas inhibition of SREBP-2 catabolism by N-acetyl-leucyl-norleucinal had an opposite effect.	4-(2-aminoethyl)benzenesulfonylfluoride	146-187	sterol regulatory element binding transcription factor 2	Homo sapiens	45-80	
19497963-6	2009	Indeed, uPA upregulated PON2 expression in a sterol regulatory binding protein-2 (SREBP-2)-dependent manner, since blocking SREBP-2 maturation by 4-(2-aminoethyl)-benzenesulfonyl fluoride abolished uPA-stimulation of PON2, whereas inhibition of SREBP-2 catabolism by N-acetyl-leucyl-norleucinal had an opposite effect.	4-(2-aminoethyl)benzenesulfonylfluoride	146-187	sterol regulatory element binding transcription factor 2	Homo sapiens	82-89	
19497963-6	2009	Indeed, uPA upregulated PON2 expression in a sterol regulatory binding protein-2 (SREBP-2)-dependent manner, since blocking SREBP-2 maturation by 4-(2-aminoethyl)-benzenesulfonyl fluoride abolished uPA-stimulation of PON2, whereas inhibition of SREBP-2 catabolism by N-acetyl-leucyl-norleucinal had an opposite effect.	4-(2-aminoethyl)benzenesulfonylfluoride	146-187	sterol regulatory element binding transcription factor 2	Homo sapiens	124-131	
19497963-6	2009	Indeed, uPA upregulated PON2 expression in a sterol regulatory binding protein-2 (SREBP-2)-dependent manner, since blocking SREBP-2 maturation by 4-(2-aminoethyl)-benzenesulfonyl fluoride abolished uPA-stimulation of PON2, whereas inhibition of SREBP-2 catabolism by N-acetyl-leucyl-norleucinal had an opposite effect.	4-(2-aminoethyl)benzenesulfonylfluoride	146-187	plasminogen activator, urokinase	Homo sapiens	198-201	
19497963-6	2009	Indeed, uPA upregulated PON2 expression in a sterol regulatory binding protein-2 (SREBP-2)-dependent manner, since blocking SREBP-2 maturation by 4-(2-aminoethyl)-benzenesulfonyl fluoride abolished uPA-stimulation of PON2, whereas inhibition of SREBP-2 catabolism by N-acetyl-leucyl-norleucinal had an opposite effect.	4-(2-aminoethyl)benzenesulfonylfluoride	146-187	paraoxonase 2	Homo sapiens	217-221	
19497963-6	2009	Indeed, uPA upregulated PON2 expression in a sterol regulatory binding protein-2 (SREBP-2)-dependent manner, since blocking SREBP-2 maturation by 4-(2-aminoethyl)-benzenesulfonyl fluoride abolished uPA-stimulation of PON2, whereas inhibition of SREBP-2 catabolism by N-acetyl-leucyl-norleucinal had an opposite effect.	4-(2-aminoethyl)benzenesulfonylfluoride	146-187	sterol regulatory element binding transcription factor 2	Homo sapiens	124-131	
19497963-6	2009	Indeed, uPA upregulated PON2 expression in a sterol regulatory binding protein-2 (SREBP-2)-dependent manner, since blocking SREBP-2 maturation by 4-(2-aminoethyl)-benzenesulfonyl fluoride abolished uPA-stimulation of PON2, whereas inhibition of SREBP-2 catabolism by N-acetyl-leucyl-norleucinal had an opposite effect.	n-acetyl-leucyl-norleucinal	267-294	plasminogen activator, urokinase	Homo sapiens	8-11	
19497963-6	2009	Indeed, uPA upregulated PON2 expression in a sterol regulatory binding protein-2 (SREBP-2)-dependent manner, since blocking SREBP-2 maturation by 4-(2-aminoethyl)-benzenesulfonyl fluoride abolished uPA-stimulation of PON2, whereas inhibition of SREBP-2 catabolism by N-acetyl-leucyl-norleucinal had an opposite effect.	n-acetyl-leucyl-norleucinal	267-294	paraoxonase 2	Homo sapiens	24-28	
19497963-6	2009	Indeed, uPA upregulated PON2 expression in a sterol regulatory binding protein-2 (SREBP-2)-dependent manner, since blocking SREBP-2 maturation by 4-(2-aminoethyl)-benzenesulfonyl fluoride abolished uPA-stimulation of PON2, whereas inhibition of SREBP-2 catabolism by N-acetyl-leucyl-norleucinal had an opposite effect.	n-acetyl-leucyl-norleucinal	267-294	sterol regulatory element binding transcription factor 2	Homo sapiens	82-89