PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19465554-1 2009 Given that the physiology of heme oxygenase-1 (HO-1) encompasses mitochondrial biogenesis, we tested the hypothesis that the HO-1 product, carbon monoxide (CO), activates mitochondrial biogenesis in skeletal muscle and enhances maximal oxygen uptake (Vo(2max)) in humans. Oxygen 34-40 heme oxygenase 1 Homo sapiens 47-51