PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19184424-0 2010 Chronic aspirin use suppresses CDH1 methylation in human gastric mucosa. Aspirin 8-15 cadherin 1 Homo sapiens 31-35 19184424-4 2010 We investigated the methylation status of CDH1 in noncancerous gastric mucosa in chronic aspirin user, and assessed its effect on methylation-associated carcinogenesis. Aspirin 89-96 cadherin 1 Homo sapiens 42-46 19184424-8 2010 CDH1 methylation more frequently occurred in H. pylori-infection-positive subjects (P < 0.0001), while chronic aspirin users had a significantly lower risk of CDH1 methylation [nonuser versus user 36.1% versus 10.8%; odds ratio (OR) = 0.21, 95% confidence interval (CI) = 0.07-0.63, P = 0.005]. Aspirin 114-121 cadherin 1 Homo sapiens 162-166 19184424-9 2010 Logistic regression analysis showed that chronic aspirin use was the independent factor for lower risk of CDH1 methylation (adjusted OR = 0.21, 95%CI = 0.07-0.66, P = 0.008). Aspirin 49-56 cadherin 1 Homo sapiens 106-110 19184424-10 2010 Chronic aspirin use was associated with lower risk of CDH1 methylation in H. pylori-positive subjects (nonuser versus user 49.5% versus 19.0%; OR = 0.24, 95%CI = 0.08-0.76, P = 0.01). Aspirin 8-15 cadherin 1 Homo sapiens 54-58 19184424-13 2010 Our data suggest that chronic aspirin use is associated with reduced risk of CDH1 methylation in human gastric mucosa. Aspirin 30-37 cadherin 1 Homo sapiens 77-81