PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19075705-2 2008 Expanded polyQ stretches have been shown to undergo a conformational transition to a beta-sheet-dominant structure, leading to assembly of the host proteins into insoluble beta-sheet-rich amyloid fibrillar aggregates and their subsequent accumulation as inclusion bodies in affected neurons, eventually resulting in neurodegeneration. polyglutamine 9-14 amyloid beta precursor protein Homo sapiens 83-89