PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19019830-5 2009 Additionally, TRPM8 activity is sensitive to the phospholipid phosphoinositol 4,5-bisphosphate (PIP2), a substrate for the enzyme phospholipase C (PLC). Phosphatidylinositol 4,5-Diphosphate 96-100 transient receptor potential cation channel subfamily M member 8 Homo sapiens 14-19 19019830-6 2009 These results suggest an adaptation model whereby TRPM8-mediated Ca2+ influx activates PLC, thereby decreasing PIP2 levels and resulting in reduced TRPM8 activity. Phosphatidylinositol 4,5-Diphosphate 111-115 transient receptor potential cation channel subfamily M member 8 Homo sapiens 50-55