PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19015277-5 2008 We further decipher the mechanistic basis for this defect in ERAD: the entrapment of the essential ERAD proteins Npl4, Ufd1, and p97 by polyQ-expanded htt fragments. polyglutamine 136-141 huntingtin Rattus norvegicus 151-154 19015277-7 2008 Our results establish that impaired ER protein homeostasis is a broad and highly conserved contributor to polyQ toxicity in yeast, in PC12 cells, and, importantly, in striatal cells expressing full-length polyQ-expanded huntingtin. polyglutamine 106-111 huntingtin Rattus norvegicus 220-230 19015277-7 2008 Our results establish that impaired ER protein homeostasis is a broad and highly conserved contributor to polyQ toxicity in yeast, in PC12 cells, and, importantly, in striatal cells expressing full-length polyQ-expanded huntingtin. polyglutamine 205-210 huntingtin Rattus norvegicus 220-230