PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19005408-0	2008	Hydrogen peroxide-induced VCAM-1 expression in pancreatic islets and beta-cells through extracellular Ca2+ influx.	Hydrogen Peroxide	0-17	vascular cell adhesion molecule 1	Homo sapiens	26-32	
19005408-4	2008	The role of Ca2+ in H2O2-induced VCAM-1 expression was investigated in beta-cell lines using an extracellular Ca2+ chelator and Ca2+-depleted media.	Hydrogen Peroxide	20-24	vascular cell adhesion molecule 1	Homo sapiens	33-39	
19005408-5	2008	Furthermore, H2O2-induced VCAM-1 expression was measured in beta-cells, pretreated with inhibitors of protein kinase C, phospholipase D, and phosphatidylinositol-3 kinase/Akt.	Hydrogen Peroxide	13-17	vascular cell adhesion molecule 1	Homo sapiens	26-32	
19005408-6	2008	Finally, H2O2-induced VCAM-1 expression was evaluated in porcine islets and rodent beta-cell lines infected with an adenovirus encoding catalase, a H2O2-removing enzyme.	Hydrogen Peroxide	9-13	vascular cell adhesion molecule 1	Homo sapiens	22-28	
19005408-6	2008	Finally, H2O2-induced VCAM-1 expression was evaluated in porcine islets and rodent beta-cell lines infected with an adenovirus encoding catalase, a H2O2-removing enzyme.	Hydrogen Peroxide	148-152	vascular cell adhesion molecule 1	Homo sapiens	22-28	
19005408-7	2008	RESULTS: H2O2 was most potent inflammatory stimulator of VCAM-1 expression in porcine islets and had the greatest effect on VCAM-1 expression by beta-cells.	Hydrogen Peroxide	9-13	vascular cell adhesion molecule 1	Homo sapiens	57-63	
19005408-7	2008	RESULTS: H2O2 was most potent inflammatory stimulator of VCAM-1 expression in porcine islets and had the greatest effect on VCAM-1 expression by beta-cells.	Hydrogen Peroxide	9-13	vascular cell adhesion molecule 1	Homo sapiens	124-130	
19005408-8	2008	Signaling pathway analysis demonstrated that extracellular Ca2+ influx was critical to H2O2-mediated VCAM-1 expression; however, protein kinase C, phospholipase D, and phosphatidylinositol-3 kinase/Akt activation were not required for VCAM-1 expression.	Hydrogen Peroxide	87-91	vascular cell adhesion molecule 1	Homo sapiens	101-107	
19005408-8	2008	Signaling pathway analysis demonstrated that extracellular Ca2+ influx was critical to H2O2-mediated VCAM-1 expression; however, protein kinase C, phospholipase D, and phosphatidylinositol-3 kinase/Akt activation were not required for VCAM-1 expression.	Hydrogen Peroxide	87-91	vascular cell adhesion molecule 1	Homo sapiens	235-241	
19005408-9	2008	Finally, catalase overexpression inhibited H2O2-induced VCAM-1 expression by islets and beta-cell lines.	Hydrogen Peroxide	43-47	vascular cell adhesion molecule 1	Homo sapiens	56-62	
19005408-10	2008	CONCLUSION: An extracellular calcium-dependent H2O2 pathway is the critical mediator of VCAM-1 expression by pancreatic islets and beta-cells.	Hydrogen Peroxide	47-51	vascular cell adhesion molecule 1	Homo sapiens	88-94