PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18804536-0	2008	Simvastatin inhibits cell cycle progression in glucose-stimulated proliferation of aortic vascular smooth muscle cells by up-regulating cyclin dependent kinase inhibitors and p53.	Simvastatin	0-11	tumor protein p53	Homo sapiens	175-178	
18804536-8	2008	We also found that simvastatin inhibited phosphorylation of Rb, promoted expression of p53, p16, p21, p27 and decreased CDK2/4 activity.	Simvastatin	19-30	tumor protein p53	Homo sapiens	87-90	
18804536-9	2008	In conclusion, simvastatin inhibits VSMC proliferation in high glucose status, mimicking diabetes, inducing a G0/G1 phase cell cycle growth arrest by acting on multiple steps upstream of pRb, including inhibition of CDK2/4 expression and up-regulation of p53, p21, p16, and p27.	Simvastatin	15-26	tumor protein p53	Homo sapiens	255-258