PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18804536-0 2008 Simvastatin inhibits cell cycle progression in glucose-stimulated proliferation of aortic vascular smooth muscle cells by up-regulating cyclin dependent kinase inhibitors and p53. Simvastatin 0-11 tumor protein p53 Homo sapiens 175-178 18804536-8 2008 We also found that simvastatin inhibited phosphorylation of Rb, promoted expression of p53, p16, p21, p27 and decreased CDK2/4 activity. Simvastatin 19-30 tumor protein p53 Homo sapiens 87-90 18804536-9 2008 In conclusion, simvastatin inhibits VSMC proliferation in high glucose status, mimicking diabetes, inducing a G0/G1 phase cell cycle growth arrest by acting on multiple steps upstream of pRb, including inhibition of CDK2/4 expression and up-regulation of p53, p21, p16, and p27. Simvastatin 15-26 tumor protein p53 Homo sapiens 255-258