PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18632984-3	2008	Here we show that Et743 induces both transcription- and replication-coupled DNA double-strand breaks (DSBs) that are detectible by neutral COMET assay and as gamma-H2AX foci that colocalize with 53BP1, Mre11, Ser(1981)-pATM, and Thr(68)-pChk2.	Trabectedin	18-23	H2A.X variant histone	Homo sapiens	164-168	
18632984-3	2008	Here we show that Et743 induces both transcription- and replication-coupled DNA double-strand breaks (DSBs) that are detectible by neutral COMET assay and as gamma-H2AX foci that colocalize with 53BP1, Mre11, Ser(1981)-pATM, and Thr(68)-pChk2.	Trabectedin	18-23	MRE11 homolog, double strand break repair nuclease	Homo sapiens	202-207	
18632984-4	2008	The transcription coupled-DSBs (TC-DSBs) induced by Et743 depended both on TCR and Mre11-Rad50-Nbs1 (MRN) and were associated with DNA-PK-dependent gamma-H2AX foci.	dsbs	26-30	MRE11 homolog, double strand break repair nuclease	Homo sapiens	83-88	
18632984-4	2008	The transcription coupled-DSBs (TC-DSBs) induced by Et743 depended both on TCR and Mre11-Rad50-Nbs1 (MRN) and were associated with DNA-PK-dependent gamma-H2AX foci.	dsbs	26-30	RAD50 double strand break repair protein	Homo sapiens	89-94	
18632984-4	2008	The transcription coupled-DSBs (TC-DSBs) induced by Et743 depended both on TCR and Mre11-Rad50-Nbs1 (MRN) and were associated with DNA-PK-dependent gamma-H2AX foci.	dsbs	26-30	nibrin	Homo sapiens	95-99	
18632984-4	2008	The transcription coupled-DSBs (TC-DSBs) induced by Et743 depended both on TCR and Mre11-Rad50-Nbs1 (MRN) and were associated with DNA-PK-dependent gamma-H2AX foci.	dsbs	26-30	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	131-137	
18632984-4	2008	The transcription coupled-DSBs (TC-DSBs) induced by Et743 depended both on TCR and Mre11-Rad50-Nbs1 (MRN) and were associated with DNA-PK-dependent gamma-H2AX foci.	dsbs	26-30	H2A.X variant histone	Homo sapiens	154-158	
18632984-4	2008	The transcription coupled-DSBs (TC-DSBs) induced by Et743 depended both on TCR and Mre11-Rad50-Nbs1 (MRN) and were associated with DNA-PK-dependent gamma-H2AX foci.	tc-dsbs	32-39	MRE11 homolog, double strand break repair nuclease	Homo sapiens	83-88	
18632984-4	2008	The transcription coupled-DSBs (TC-DSBs) induced by Et743 depended both on TCR and Mre11-Rad50-Nbs1 (MRN) and were associated with DNA-PK-dependent gamma-H2AX foci.	tc-dsbs	32-39	RAD50 double strand break repair protein	Homo sapiens	89-94	
18632984-4	2008	The transcription coupled-DSBs (TC-DSBs) induced by Et743 depended both on TCR and Mre11-Rad50-Nbs1 (MRN) and were associated with DNA-PK-dependent gamma-H2AX foci.	tc-dsbs	32-39	nibrin	Homo sapiens	95-99	
18632984-4	2008	The transcription coupled-DSBs (TC-DSBs) induced by Et743 depended both on TCR and Mre11-Rad50-Nbs1 (MRN) and were associated with DNA-PK-dependent gamma-H2AX foci.	tc-dsbs	32-39	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	131-137	
18632984-4	2008	The transcription coupled-DSBs (TC-DSBs) induced by Et743 depended both on TCR and Mre11-Rad50-Nbs1 (MRN) and were associated with DNA-PK-dependent gamma-H2AX foci.	tc-dsbs	32-39	H2A.X variant histone	Homo sapiens	154-158	
18632984-4	2008	The transcription coupled-DSBs (TC-DSBs) induced by Et743 depended both on TCR and Mre11-Rad50-Nbs1 (MRN) and were associated with DNA-PK-dependent gamma-H2AX foci.	Trabectedin	52-57	MRE11 homolog, double strand break repair nuclease	Homo sapiens	83-88	
18632984-4	2008	The transcription coupled-DSBs (TC-DSBs) induced by Et743 depended both on TCR and Mre11-Rad50-Nbs1 (MRN) and were associated with DNA-PK-dependent gamma-H2AX foci.	Trabectedin	52-57	RAD50 double strand break repair protein	Homo sapiens	89-94	
18632984-4	2008	The transcription coupled-DSBs (TC-DSBs) induced by Et743 depended both on TCR and Mre11-Rad50-Nbs1 (MRN) and were associated with DNA-PK-dependent gamma-H2AX foci.	Trabectedin	52-57	nibrin	Homo sapiens	95-99	
18632984-4	2008	The transcription coupled-DSBs (TC-DSBs) induced by Et743 depended both on TCR and Mre11-Rad50-Nbs1 (MRN) and were associated with DNA-PK-dependent gamma-H2AX foci.	Trabectedin	52-57	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	131-137	
18632984-4	2008	The transcription coupled-DSBs (TC-DSBs) induced by Et743 depended both on TCR and Mre11-Rad50-Nbs1 (MRN) and were associated with DNA-PK-dependent gamma-H2AX foci.	Trabectedin	52-57	H2A.X variant histone	Homo sapiens	154-158