PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18582539-0	2008	Tumor necrosis factor alpha enhances the sensitivity of rat trigeminal neurons to capsaicin.	Capsaicin	82-91	tumor necrosis factor	Rattus norvegicus	0-27	
18582539-2	2008	This study evaluated the hypothesis that TNFalpha increases the sensitivity of rat trigeminal neurons to capsaicin via two different mechanisms triggered by either brief or sustained exposure to the cytokine.	Capsaicin	105-114	tumor necrosis factor	Rattus norvegicus	41-49	
18582539-3	2008	A brief (5 min) application of TNFalpha significantly sensitized capsaicin-evoked accumulation of intracellular calcium ([Ca2+]i) (226.4+/-37.7 nM vs. 167.5+/-31.3 nM) and increased capsaicin-evoked nocifensive behavior (78.3+/-9.7 vs. 30.9+/-3.6 s) as compared with vehicle pretreatment (P<0.01 for both).	Capsaicin	65-74	tumor necrosis factor	Rattus norvegicus	31-39	
18582539-3	2008	A brief (5 min) application of TNFalpha significantly sensitized capsaicin-evoked accumulation of intracellular calcium ([Ca2+]i) (226.4+/-37.7 nM vs. 167.5+/-31.3 nM) and increased capsaicin-evoked nocifensive behavior (78.3+/-9.7 vs. 30.9+/-3.6 s) as compared with vehicle pretreatment (P<0.01 for both).	Capsaicin	182-191	tumor necrosis factor	Rattus norvegicus	31-39	
18582539-5	2008	This long-term up-regulation of TRPV1 expression by TNFalpha correlated with enhancement in capsaicin-induced calcitonin gene-related peptide release (P<0.05).	Capsaicin	92-101	tumor necrosis factor	Rattus norvegicus	52-60	
18582539-7	2008	In summary, our data demonstrate that TNFalpha directly enhances the sensitivity of rat trigeminal neurons to capsaicin via both rapid, non-genomic mechanisms as well as sustained genomic regulation in TRPV1 expression.	Capsaicin	110-119	tumor necrosis factor	Rattus norvegicus	38-46