PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17998932-6 2008 In cell lines ensuing from benzo(a)pyrene-treated cultures the combined p53 mutation pattern from experiments with the 3 codon 72 genotypes showed a predominance of strand-biased G to T transversions (18 of 36 mutations), and mutations recurring at smokers" lung tumour hotspot codons 157 and 273, supporting involvement of tobacco carcinogens in shaping the mutation signature in lung cancers of smokers. Benzo(a)pyrene 27-41 tumor protein p53 Homo sapiens 72-75