PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17997002-6 2008 Arecoline (0.5mM) also increased p21(WAF1) protein expression and p21(WAF1) gene transcription. Arecoline 0-9 KRAS proto-oncogene, GTPase Rattus norvegicus 33-36 17997002-6 2008 Arecoline (0.5mM) also increased p21(WAF1) protein expression and p21(WAF1) gene transcription. Arecoline 0-9 KRAS proto-oncogene, GTPase Rattus norvegicus 66-69 17997002-8 2008 Pifithrin-alpha (p53 inhibitor) and the loss of the two p53-binding elements in the p21(WAF1) gene promoter attenuated arecoline-induced p21(WAF1) gene transcription at 24h. Arecoline 119-128 KRAS proto-oncogene, GTPase Rattus norvegicus 84-87 17997002-8 2008 Pifithrin-alpha (p53 inhibitor) and the loss of the two p53-binding elements in the p21(WAF1) gene promoter attenuated arecoline-induced p21(WAF1) gene transcription at 24h. Arecoline 119-128 KRAS proto-oncogene, GTPase Rattus norvegicus 137-140 17997002-10 2008 We concluded that arecoline induces cytotoxicity, DNA damage, G(0)/G(1) cell cycle arrest, TGF-beta1, p21(WAF1) and activates p53 in Clone-9 cells. Arecoline 18-27 KRAS proto-oncogene, GTPase Rattus norvegicus 102-105 17997002-11 2008 Moreover, arecoline-induced p21(WAF1) is dependent on p53 while arecoline-inhibited growth is dependent on both TGF-beta and p53. Arecoline 10-19 KRAS proto-oncogene, GTPase Rattus norvegicus 28-31