PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17972021-6 2007 Cells exposed to hypoxia generate reactive oxygen species which activate PKC zeta which in turn phosphorylates the Na,K-ATPase at the Ser18 residue in the N-terminus of the alpha1-subunit leading the ubiquitination of any of the four lysines (K16, K17, K19, K20) adjacent to the Ser18 residue. Reactive Oxygen Species 34-57 keratin 20 Homo sapiens 258-261