PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1796634-6 1991 In more severe heart failure vasoconstrictor, sodium and water-retaining mechanisms like the renin-angiotensin-aldosterone system are activated with the consequence of an increase of systemic vascular resistance, a reduction of renal blood flow, and an increased fluid retention. Water 57-62 renin Homo sapiens 93-98