PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17942461-0 2008 Identification through microarray gene expression analysis of cellular responses to benzo(a)pyrene and its diol-epoxide that are dependent or independent of p53. Benzo(a)pyrene 84-98 tumor protein p53 Homo sapiens 157-160 17942461-7 2008 Interestingly, DNA adduct formation after BaP, but not BPDE, exposure was p53 dependent with 10-fold lower levels detected in p53-null cells. Benzo(a)pyrene 42-45 tumor protein p53 Homo sapiens 74-77 17942461-7 2008 Interestingly, DNA adduct formation after BaP, but not BPDE, exposure was p53 dependent with 10-fold lower levels detected in p53-null cells. Benzo(a)pyrene 42-45 tumor protein p53 Homo sapiens 126-129 17942461-8 2008 Other cell lines were investigated for BaP-DNA adduct formation and in these the effect of p53 knockdown was also to reduce adduct formation. Benzo(a)pyrene 39-42 tumor protein p53 Homo sapiens 91-94 17942461-9 2008 Taken together, these results give further insight into the role of p53 in the response of human cells to BaP and BPDE and suggest that loss of this tumour suppressor can influence the metabolic activation of BaP. Benzo(a)pyrene 106-109 tumor protein p53 Homo sapiens 68-71 17942461-9 2008 Taken together, these results give further insight into the role of p53 in the response of human cells to BaP and BPDE and suggest that loss of this tumour suppressor can influence the metabolic activation of BaP. Benzo(a)pyrene 209-212 tumor protein p53 Homo sapiens 68-71