PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17684410-3 2007 We found that functional polymorphisms in methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase (TS), two key enzymes involved in folate and methyl group metabolism, were significantly associated with increased risk of esophageal squamous cell carcinoma, gastric cardia carcinoma, and pancreatic carcinoma. Folic Acid 61-67 thymidylate synthetase Homo sapiens 90-110 17684410-3 2007 We found that functional polymorphisms in methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase (TS), two key enzymes involved in folate and methyl group metabolism, were significantly associated with increased risk of esophageal squamous cell carcinoma, gastric cardia carcinoma, and pancreatic carcinoma. Folic Acid 61-67 thymidylate synthetase Homo sapiens 112-114