PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17551816-2 2007 O(2)-dependent hydroxylation of two proline residues in the HIF-1alpha subunit is necessary for the binding of the von Hippel-Lindau (VHL) protein, which is a component of a ubiquitin protein ligase that ubiquitinates HIF-1alpha, leading to its degradation by the proteasome. Proline 36-43 von Hippel-Lindau tumor suppressor Homo sapiens 115-132 17551816-2 2007 O(2)-dependent hydroxylation of two proline residues in the HIF-1alpha subunit is necessary for the binding of the von Hippel-Lindau (VHL) protein, which is a component of a ubiquitin protein ligase that ubiquitinates HIF-1alpha, leading to its degradation by the proteasome. Proline 36-43 von Hippel-Lindau tumor suppressor Homo sapiens 134-137