PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17509533-0 2007 The effect of quercetin phase II metabolism on its MRP1 and MRP2 inhibiting potential. Quercetin 14-23 ATP binding cassette subfamily C member 1 Homo sapiens 51-55 17509533-1 2007 The present study characterises the effect of phase II metabolism, especially methylation and glucuronidation, of the model flavonoid quercetin on its capacity to inhibit human MRP1 and MRP2 activity in Sf9 inside-out vesicles. Quercetin 134-143 ATP binding cassette subfamily C member 1 Homo sapiens 177-181 17509533-5 2007 Overall, the results of this study reveal that the major phase II metabolites of quercetin are equally potent or even better inhibitors of human MRP1 and MRP2 than quercetin itself. Quercetin 81-90 ATP binding cassette subfamily C member 1 Homo sapiens 145-149 17509533-6 2007 This finding indicates that phase II metabolism of quercetin could enhance the potential use of quercetin- or flavonoids in general-as an inhibitor to overcome MRP-mediated multidrug resistance. Quercetin 51-60 ATP binding cassette subfamily C member 1 Homo sapiens 160-163 17509533-6 2007 This finding indicates that phase II metabolism of quercetin could enhance the potential use of quercetin- or flavonoids in general-as an inhibitor to overcome MRP-mediated multidrug resistance. Quercetin 96-105 ATP binding cassette subfamily C member 1 Homo sapiens 160-163