PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17505827-1 2008 PURPOSE: Sunitinib, an oral multitargeted tyrosine kinase inhibitor that inhibits VEGFR, PDGFR, FLT3, KIT, and RET, is currently approved for the treatment of imatinib-refractory GIST and advanced renal cell carcinoma at a dose of 50 mg daily for 4 weeks followed by a 2-week off period (4/2 schedule). Sunitinib 9-18 ret proto-oncogene Homo sapiens 111-114