PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17431384-2 2007 AIM: This study was designed to investigate the role of COX-2 inhibitor nimesulide in cell growth and apoptosis of the cultured human hepatocellular carcinoma HepG2 cells. nimesulide 72-82 mitochondrially encoded cytochrome c oxidase II Homo sapiens 56-61 17431384-4 2007 RESULTS: Our results showed that the treatment of HepG2 cells with more than 50 microM of nimesulide suppressed COX-2 enzyme activity because of reduced PGE(2) production, and then induced growth inhibition and cell apoptosis despite no alterations of COX-2 protein expression. nimesulide 90-100 mitochondrially encoded cytochrome c oxidase II Homo sapiens 112-117 17431384-4 2007 RESULTS: Our results showed that the treatment of HepG2 cells with more than 50 microM of nimesulide suppressed COX-2 enzyme activity because of reduced PGE(2) production, and then induced growth inhibition and cell apoptosis despite no alterations of COX-2 protein expression. nimesulide 90-100 mitochondrially encoded cytochrome c oxidase II Homo sapiens 252-257