PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1737390-6 1992 TPA induced rapid translocation of the PKC-alpha isozyme and PKC activity to the membrane fraction of MCF-7 cells. Tetradecanoylphorbol Acetate 0-3 protein kinase C alpha Homo sapiens 39-48 1737390-6 1992 TPA induced rapid translocation of the PKC-alpha isozyme and PKC activity to the membrane fraction of MCF-7 cells. Tetradecanoylphorbol Acetate 0-3 protein kinase C alpha Homo sapiens 39-42 1737390-9 1992 Similar effects on PKC-alpha isozyme and PKC activity were seen in a second cell line whose growth was inhibited by TPA but not by bryostatin 1, MDA-MB-468. Tetradecanoylphorbol Acetate 116-119 protein kinase C alpha Homo sapiens 19-28 1737390-9 1992 Similar effects on PKC-alpha isozyme and PKC activity were seen in a second cell line whose growth was inhibited by TPA but not by bryostatin 1, MDA-MB-468. Tetradecanoylphorbol Acetate 116-119 protein kinase C alpha Homo sapiens 19-22 1737390-12 1992 Thus, differential actions of bryostatin 1 and TPA on PKC activity and alpha-isoform level in the membrane-associated fraction of MCF-7 and MDA-MB-468 cells may account for the divergent effects of these two agents on cell growth and morphology. Tetradecanoylphorbol Acetate 47-50 protein kinase C alpha Homo sapiens 54-57