PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17365862-0	2007	Epinephrine induces intracellular Ca2+ mobilization in thrombin-desensitized platelets: a role for GPIb-IX-V.	Epinephrine	0-11	coagulation factor II, thrombin	Homo sapiens	55-63	
17365862-1	2007	In this work we have investigated the ability of epinephrine to trigger the release of intracellular Ca2+ in thrombin-desensitized platelets.	Epinephrine	49-60	coagulation factor II, thrombin	Homo sapiens	109-117	
17365862-3	2007	Although epinephrine alone had no effect on intracellular Ca2+ mobilization, its addition to thrombin-desensitized platelets was associated to a rapid and evident secondary release of intracellular Ca2+.	Epinephrine	9-20	coagulation factor II, thrombin	Homo sapiens	93-101	
17365862-6	2007	Addition of hirudin to thrombin-desensitized platelets prevented epinephrine-promoted secondary release of Ca2+, indicating that thrombin, rather than epinephrine itself, is actually responsible for this event as a consequence of thrombin receptors resensitization.	Epinephrine	65-76	coagulation factor II, thrombin	Homo sapiens	23-31	
17365862-6	2007	Addition of hirudin to thrombin-desensitized platelets prevented epinephrine-promoted secondary release of Ca2+, indicating that thrombin, rather than epinephrine itself, is actually responsible for this event as a consequence of thrombin receptors resensitization.	Epinephrine	65-76	coagulation factor II, thrombin	Homo sapiens	129-137	
17365862-6	2007	Addition of hirudin to thrombin-desensitized platelets prevented epinephrine-promoted secondary release of Ca2+, indicating that thrombin, rather than epinephrine itself, is actually responsible for this event as a consequence of thrombin receptors resensitization.	Epinephrine	65-76	coagulation factor II, thrombin	Homo sapiens	129-137	
17365862-8	2007	Moreover, we found that thrombin was still able to induce a reduced, but evident release of Ca2+ from internal stores in PAR1- and PAR4-desensitized platelets, which could be followed by a secondary Ca2+ release upon subsequent addition of epinephrine.	Epinephrine	240-251	coagulation factor II, thrombin	Homo sapiens	24-32	
17365862-10	2007	These results demonstrate a direct role of thrombin binding to GPIb-IX-V in the mobilization of Ca2+ from intracellular stores, and reveal that epinephrine can restore this process in desensitized platelets, thus prolonging the effect of thrombin stimulation.	Epinephrine	144-155	coagulation factor II, thrombin	Homo sapiens	238-246