PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17300043-2 2006 The study was based on the discovery of novel adenylyl cyclase signaling mechanisms of relaxin and insulin action in the muscle of vertebrates which involve: receptor --> Gi protein (betagamma dimer) --> phosphatidylinositol-3-kinase --> protein kinase Csigma (zeta) --> Gs protein --> adenylyl cyclase --> cAMP. Cyclic AMP 325-329 insulin Homo sapiens 99-106