PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16938121-0	2006	Histamine differentially interacts with tumor necrosis factor-alpha and thrombin in endothelial tissue factor induction: the role of c-Jun NH2-terminal kinase.	Histamine	0-9	coagulation factor II, thrombin	Homo sapiens	72-80	
16938121-9	2006	Histamine-induced p38 activation preceded a weak second activation to both TNF-alpha and thrombin.	Histamine	0-9	coagulation factor II, thrombin	Homo sapiens	89-97	
16938121-10	2006	Histamine-induced c-Jun NH2-terminal kinase (JNK) activation was followed by a strong second activation to TNF-alpha, and less to thrombin.	Histamine	0-9	coagulation factor II, thrombin	Homo sapiens	130-138	
16938121-12	2006	Histamine augmented TNF-alpha- and thrombin-induced vascular cell adhesion molecule 1 (VCAM-1) expression to a similar extent.	Histamine	0-9	coagulation factor II, thrombin	Homo sapiens	35-43	
16938121-14	2006	CONCLUSIONS: Histamine differentially augments TNF-alpha- vs. thrombin-induced TF expression and activity, which is mediated by the H1-receptor, occurs at the mRNA level, and is related to differential JNK activation.	Histamine	13-22	coagulation factor II, thrombin	Homo sapiens	62-70