PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16920098-3 2006 Histamine and amthamine, a selective histamine H(2)-receptor agonist, concentration-dependently decreased myogenic tone, which was unchanged in the absence of endothelium. Histamine 0-9 histamine receptor H 2 Rattus norvegicus 37-60 16920098-6 2006 The dilation to histamine was antagonized by tiotidine, a selective antagonist of histamine H(2)-receptor subtype, giving a pK(B) of 7.86 that was not altered in the absence of endothelium. Histamine 16-25 histamine receptor H 2 Rattus norvegicus 82-105 16920098-11 2006 These results suggest that histamine-mediated reversal of myogenic tone in rat cerebral arteries is endothelium-independent, mediated by histamine H(2)-receptor subtype with no involvement of guanylyl cyclase or adenylyl cyclase activation and most likely involves activation of K(V) potassium channels. Histamine 27-36 histamine receptor H 2 Rattus norvegicus 137-160