PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1691710-5 1990 We have developed a monoclonal antibody to p53 designated PAb240 which does not immunoprecipitate wild type p53. pab240 58-64 tumor protein p53 Homo sapiens 43-46 1691710-6 1990 A series of different p53 mutants all react more strongly with PAb240 than with PAb246. pab240 63-69 tumor protein p53 Homo sapiens 22-25 1691710-6 1990 A series of different p53 mutants all react more strongly with PAb240 than with PAb246. pab246 80-86 tumor protein p53 Homo sapiens 22-25 1691710-7 1990 The PAb240 reactive form of p53 cannot bind to SV40 large T antigen but does bind to HSP70. pab240 4-10 tumor protein p53 Homo sapiens 28-31 1691710-7 1990 The PAb240 reactive form of p53 cannot bind to SV40 large T antigen but does bind to HSP70. pab240 4-10 heat shock protein family A (Hsp70) member 4 Homo sapiens 85-90 1691710-9 1990 PAb240 recognizes all forms of p53 when they are denatured. pab240 0-6 tumor protein p53 Homo sapiens 31-34 1691710-11 1990 We propose that immunoprecipitation of p53 by PAb240 is diagnostic of mutation in both murine and human systems and suggest that the different point mutations which convert p53 from a recessive to a dominant oncogene exert a common conformational effect on the protein. pab240 46-52 transformation related protein 53, pseudogene Mus musculus 39-42 1691710-11 1990 We propose that immunoprecipitation of p53 by PAb240 is diagnostic of mutation in both murine and human systems and suggest that the different point mutations which convert p53 from a recessive to a dominant oncogene exert a common conformational effect on the protein. pab240 46-52 tumor protein p53 Homo sapiens 173-176