PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16893669-0 2006 Modulation of ERK 1/2 and p38 MAPK signaling pathways by ATP in osteoblasts: involvement of mechanical stress-activated calcium influx, PKC and Src activation. Adenosine Triphosphate 57-60 mitogen-activated protein kinase 1 Homo sapiens 26-29 16893669-6 2006 In addition, ERK 1/2 and p38 MAPK were activated by ATP in a dose- and time-dependent manner. Adenosine Triphosphate 52-55 mitogen-activated protein kinase 1 Homo sapiens 25-28 16893669-8 2006 Ca(2+)-free extracellular medium (containing 0.5mM EGTA) and the use of gadolinium (5 microM), which suppressed MSACI, prevented ERK 1/2 and p38 phosphorylation by ATP. Adenosine Triphosphate 164-167 mitogen-activated protein kinase 1 Homo sapiens 141-144 16893669-9 2006 Altogether, these results represent the first evidence to date suggesting that P2Y(2) receptor stimulation by ATP in osteoblasts sensitizes mechanical stress activated calcium channels leading to calcium influx and a fast activation of the ERK 1/2 and p38 MAPK pathways. Adenosine Triphosphate 110-113 mitogen-activated protein kinase 1 Homo sapiens 252-255