PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16874462-1 2007 Proline oxidase (POX), a mitochondrial inner-membrane protein, catalyzes the rate-limiting oxidation of proline to pyrroline- 5-carboxylate (P5C). Proline 104-111 proline dehydrogenase 1 Homo sapiens 0-15 16874462-1 2007 Proline oxidase (POX), a mitochondrial inner-membrane protein, catalyzes the rate-limiting oxidation of proline to pyrroline- 5-carboxylate (P5C). Proline 104-111 proline dehydrogenase 1 Homo sapiens 17-20 16874462-4 2007 To further investigate the molecular basis of POX-induced apoptosis, we utilized the DLD-1.POX cells to show that cells overproducing POX exhibit an L-proline-dependent apoptotic response. Proline 149-158 proline dehydrogenase 1 Homo sapiens 46-49 16874462-4 2007 To further investigate the molecular basis of POX-induced apoptosis, we utilized the DLD-1.POX cells to show that cells overproducing POX exhibit an L-proline-dependent apoptotic response. Proline 149-158 proline dehydrogenase 1 Homo sapiens 91-94 16874462-4 2007 To further investigate the molecular basis of POX-induced apoptosis, we utilized the DLD-1.POX cells to show that cells overproducing POX exhibit an L-proline-dependent apoptotic response. Proline 149-158 proline dehydrogenase 1 Homo sapiens 91-94 16874462-5 2007 The apoptotic effect is specific for L-proline, detectable at 0.2 mM, maximal at 1 mM, and occurs during 48-72 h following the addition of L-proline to cells with maximally induced POX. Proline 37-46 proline dehydrogenase 1 Homo sapiens 181-184 16874462-5 2007 The apoptotic effect is specific for L-proline, detectable at 0.2 mM, maximal at 1 mM, and occurs during 48-72 h following the addition of L-proline to cells with maximally induced POX. Proline 139-148 proline dehydrogenase 1 Homo sapiens 181-184 16874462-7 2007 We conclude that in the presence of proline, high POX activity is sufficient to induce mitochondria-mediated apoptosis. Proline 36-43 proline dehydrogenase 1 Homo sapiens 50-53