PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16861746-1 2006 BACKGROUND: Three typical folate metabolism enzymes-i.e. methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MS) and MS reductase (MTRR) in the folate cycle-play a critical role in DNA synthesis and methylation reactions. Folic Acid 26-32 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 102-121