PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16789993-0 2006 Effect of CYP2C19 genetic polymorphism on pharmacokinetics of phenytoin and phenobarbital in Japanese epileptic patients using Non-linear Mixed Effects Model approach. Phenobarbital 76-89 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 10-17 16789993-1 2006 OBJECTIVE: To clarify the effect of genetic polymorphism of CYP2C19 on pharmacokinetics of phenytoin and phenobarbital using a Non-linear Mixed Effects Modelling analysis in Japanese epileptic patients. Phenobarbital 105-118 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 60-67 16789993-5 2006 The total body clearance of phenobarbital decreased by 19.3% in patients with CYP2C19*1/*3 or the poor metabolizers of CYP2C19 compared with patients with normal CYP2C19 or with CYP2C19*1/*2. Phenobarbital 28-41 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 78-85 16789993-5 2006 The total body clearance of phenobarbital decreased by 19.3% in patients with CYP2C19*1/*3 or the poor metabolizers of CYP2C19 compared with patients with normal CYP2C19 or with CYP2C19*1/*2. Phenobarbital 28-41 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 119-126 16789993-5 2006 The total body clearance of phenobarbital decreased by 19.3% in patients with CYP2C19*1/*3 or the poor metabolizers of CYP2C19 compared with patients with normal CYP2C19 or with CYP2C19*1/*2. Phenobarbital 28-41 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 119-126 16789993-5 2006 The total body clearance of phenobarbital decreased by 19.3% in patients with CYP2C19*1/*3 or the poor metabolizers of CYP2C19 compared with patients with normal CYP2C19 or with CYP2C19*1/*2. Phenobarbital 28-41 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 119-126 16789993-6 2006 CONCLUSION: These findings indicated that the genetic polymorphisms of CYP2C19 contribute to the pharmacokinetic variability of phenytoin and phenobarbital, the poor metabolizers of CYP2C19, which are relatively common in Asian groups. Phenobarbital 142-155 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 71-78 16789993-6 2006 CONCLUSION: These findings indicated that the genetic polymorphisms of CYP2C19 contribute to the pharmacokinetic variability of phenytoin and phenobarbital, the poor metabolizers of CYP2C19, which are relatively common in Asian groups. Phenobarbital 142-155 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 182-189