PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16754784-9	2006	Together, the results from this study reveal that cannabidiol, acting through CB2 and regulation of Nox4 and p22(phox) expression, may be a novel and highly selective treatment for leukemia.	Cannabidiol	50-61	cannabinoid receptor 2	Homo sapiens	78-81	
16754784-0	2006	Cannabidiol-induced apoptosis in human leukemia cells: A novel role of cannabidiol in the regulation of p22phox and Nox4 expression.	Cannabidiol	0-11	cytochrome b-245 alpha chain	Homo sapiens	104-111	
16754784-0	2006	Cannabidiol-induced apoptosis in human leukemia cells: A novel role of cannabidiol in the regulation of p22phox and Nox4 expression.	Cannabidiol	0-11	NADPH oxidase 4	Homo sapiens	116-120	
16754784-0	2006	Cannabidiol-induced apoptosis in human leukemia cells: A novel role of cannabidiol in the regulation of p22phox and Nox4 expression.	Cannabidiol	71-82	cytochrome b-245 alpha chain	Homo sapiens	104-111	
16754784-0	2006	Cannabidiol-induced apoptosis in human leukemia cells: A novel role of cannabidiol in the regulation of p22phox and Nox4 expression.	Cannabidiol	71-82	NADPH oxidase 4	Homo sapiens	116-120	
16754784-2	2006	Exposure of leukemia cells to cannabidiol led to cannabinoid receptor 2 (CB2)-mediated reduction in cell viability and induction in apoptosis.	Cannabidiol	30-41	cannabinoid receptor 2	Homo sapiens	49-71	
16754784-2	2006	Exposure of leukemia cells to cannabidiol led to cannabinoid receptor 2 (CB2)-mediated reduction in cell viability and induction in apoptosis.	Cannabidiol	30-41	cannabinoid receptor 2	Homo sapiens	73-76	
16754784-4	2006	From a mechanistic standpoint, cannabidiol exposure resulted in activation of caspase-8, caspase-9, and caspase-3, cleavage of poly(ADP-ribose) polymerase, and a decrease in full-length Bid, suggesting possible cross-talk between the intrinsic and extrinsic apoptotic pathways.	Cannabidiol	31-42	caspase 8	Homo sapiens	78-87	
16754784-4	2006	From a mechanistic standpoint, cannabidiol exposure resulted in activation of caspase-8, caspase-9, and caspase-3, cleavage of poly(ADP-ribose) polymerase, and a decrease in full-length Bid, suggesting possible cross-talk between the intrinsic and extrinsic apoptotic pathways.	Cannabidiol	31-42	caspase 9	Homo sapiens	89-98	
16754784-4	2006	From a mechanistic standpoint, cannabidiol exposure resulted in activation of caspase-8, caspase-9, and caspase-3, cleavage of poly(ADP-ribose) polymerase, and a decrease in full-length Bid, suggesting possible cross-talk between the intrinsic and extrinsic apoptotic pathways.	Cannabidiol	31-42	caspase 3	Homo sapiens	104-113	
16754784-4	2006	From a mechanistic standpoint, cannabidiol exposure resulted in activation of caspase-8, caspase-9, and caspase-3, cleavage of poly(ADP-ribose) polymerase, and a decrease in full-length Bid, suggesting possible cross-talk between the intrinsic and extrinsic apoptotic pathways.	Cannabidiol	31-42	poly(ADP-ribose) polymerase 1	Homo sapiens	127-154	
16754784-4	2006	From a mechanistic standpoint, cannabidiol exposure resulted in activation of caspase-8, caspase-9, and caspase-3, cleavage of poly(ADP-ribose) polymerase, and a decrease in full-length Bid, suggesting possible cross-talk between the intrinsic and extrinsic apoptotic pathways.	Cannabidiol	31-42	BH3 interacting domain death agonist	Homo sapiens	186-189	
16754784-5	2006	The role of the mitochondria was further suggested as exposure to cannabidiol led to loss of mitochondrial membrane potential and release of cytochrome c.	Cannabidiol	66-77	cytochrome c, somatic	Homo sapiens	141-153	
16754784-6	2006	It is noteworthy that cannabidiol exposure led to an increase in reactive oxygen species (ROS) production as well as an increase in the expression of the NAD(P)H oxidases Nox4 and p22(phox).	Cannabidiol	22-33	NADPH oxidase 4	Homo sapiens	171-175	
16754784-6	2006	It is noteworthy that cannabidiol exposure led to an increase in reactive oxygen species (ROS) production as well as an increase in the expression of the NAD(P)H oxidases Nox4 and p22(phox).	Cannabidiol	22-33	calcineurin like EF-hand protein 1	Homo sapiens	180-183	
16754784-8	2006	Finally, cannabidiol exposure led to a decrease in the levels of p-p38 mitogen-activated protein kinase, which could be blocked by treatment with a CB2-selective antagonist or ROS scavenger.	Cannabidiol	9-20	cannabinoid receptor 2	Homo sapiens	148-151	
16754784-9	2006	Together, the results from this study reveal that cannabidiol, acting through CB2 and regulation of Nox4 and p22(phox) expression, may be a novel and highly selective treatment for leukemia.	Cannabidiol	50-61	NADPH oxidase 4	Homo sapiens	100-104	
16754784-9	2006	Together, the results from this study reveal that cannabidiol, acting through CB2 and regulation of Nox4 and p22(phox) expression, may be a novel and highly selective treatment for leukemia.	Cannabidiol	50-61	calcineurin like EF-hand protein 1	Homo sapiens	109-112