PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16705148-6 2006 Maintaining the cells in thiamin-deficient medium led to a significant (P < 0.01) and specific upregulation in [(3)H]thiamin uptake, which was associated with an increase in hTHTR-1 and hTHTR-2 protein and mRNA levels as well as promoter activities. Thiamine 25-32 solute carrier family 19 member 3 Homo sapiens 189-196 16705148-6 2006 Maintaining the cells in thiamin-deficient medium led to a significant (P < 0.01) and specific upregulation in [(3)H]thiamin uptake, which was associated with an increase in hTHTR-1 and hTHTR-2 protein and mRNA levels as well as promoter activities. Thiamine 120-127 solute carrier family 19 member 3 Homo sapiens 189-196 16705148-8 2006 These studies demonstrate for the first time that thiamin uptake by HEK-293 cells is mediated via a specific pH-dependent process, which involves both the hTHTR-1 and hTHTR-2. Thiamine 50-57 solute carrier family 19 member 3 Homo sapiens 167-174 16705148-9 2006 In addition, the uptake process appears to be under the regulation of an intracellular Ca(2+)/CaM-mediated pathway and also adaptively upregulated in thiamin deficiency via transcriptional regulatory mechanism(s) that involves both the hTHTR-1 and hTHTR-2. Thiamine 150-157 solute carrier family 19 member 3 Homo sapiens 248-255