PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16646054-0 2006 Dietary folate is associated with p16(INK4A) methylation in head and neck squamous cell carcinoma. Folic Acid 8-14 cyclin dependent kinase inhibitor 2A Homo sapiens 34-37 16646054-0 2006 Dietary folate is associated with p16(INK4A) methylation in head and neck squamous cell carcinoma. Folic Acid 8-14 cyclin dependent kinase inhibitor 2A Homo sapiens 38-43 16646054-3 2006 Decreased dietary folate in an animal model of hepatocellular carcinoma has been associated with the induction of epigenetic silencing of the p16(INK4A) gene. Folic Acid 18-24 cyclin dependent kinase inhibitor 2A Homo sapiens 142-145 16646054-3 2006 Decreased dietary folate in an animal model of hepatocellular carcinoma has been associated with the induction of epigenetic silencing of the p16(INK4A) gene. Folic Acid 18-24 cyclin dependent kinase inhibitor 2A Homo sapiens 146-151 16646054-4 2006 In an ongoing population-based study of HNSCC, we sought to extend this observation to human disease testing the hypothesis that p16(INK4A) methylation is associated with decreased dietary folate. Folic Acid 189-195 cyclin dependent kinase inhibitor 2A Homo sapiens 129-132 16646054-4 2006 In an ongoing population-based study of HNSCC, we sought to extend this observation to human disease testing the hypothesis that p16(INK4A) methylation is associated with decreased dietary folate. Folic Acid 189-195 cyclin dependent kinase inhibitor 2A Homo sapiens 133-138 16646054-6 2006 In 169 HNSCCs, the odds ratio for p16(INK4A) methylation among those with low dietary folate intake was 2.3 (95% CI = 1.1-4.8) when compared with those with high folate intake. Folic Acid 86-92 cyclin dependent kinase inhibitor 2A Homo sapiens 34-37 16646054-6 2006 In 169 HNSCCs, the odds ratio for p16(INK4A) methylation among those with low dietary folate intake was 2.3 (95% CI = 1.1-4.8) when compared with those with high folate intake. Folic Acid 86-92 cyclin dependent kinase inhibitor 2A Homo sapiens 38-43 16646054-7 2006 Furthermore, this increased risk for epigenetic silencing at p16(INK4A) was modified by the MTHFR alleles previously associated with diminished serum folate levels. Folic Acid 150-156 cyclin dependent kinase inhibitor 2A Homo sapiens 61-64 16646054-7 2006 Furthermore, this increased risk for epigenetic silencing at p16(INK4A) was modified by the MTHFR alleles previously associated with diminished serum folate levels. Folic Acid 150-156 cyclin dependent kinase inhibitor 2A Homo sapiens 65-70 16646054-8 2006 Hence, in HNSCC low dietary intake of folate is associated with p16(INK4A) methylation, and this relationship is modified by the MTHFR genotype. Folic Acid 38-44 cyclin dependent kinase inhibitor 2A Homo sapiens 64-67 16646054-8 2006 Hence, in HNSCC low dietary intake of folate is associated with p16(INK4A) methylation, and this relationship is modified by the MTHFR genotype. Folic Acid 38-44 cyclin dependent kinase inhibitor 2A Homo sapiens 68-73