PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16631521-0	2006	Heme oxygenase-1 contributes to the cytoprotection of alpha-lipoic acid via activation of p44/42 mitogen-activated protein kinase in vascular smooth muscle cells.	Thioctic Acid	54-71	heme oxygenase 1	Homo sapiens	0-16	
16631521-4	2006	ALA significantly induced HO-1 expression accompanied by an increase in HO activity in A10 cells.	Thioctic Acid	0-3	heme oxygenase 1	Homo sapiens	26-30	
16631521-7	2006	ALA significantly increased ROS, and this effect was blocked by N-acetyl-cysteine, which also inhibited ALA-induced activation of p44/42 mitogen-activated protein kinase (MAPK) and AP-1, HO-1 expression, and HO activity.	Thioctic Acid	0-3	heme oxygenase 1	Homo sapiens	187-191	
16631521-7	2006	ALA significantly increased ROS, and this effect was blocked by N-acetyl-cysteine, which also inhibited ALA-induced activation of p44/42 mitogen-activated protein kinase (MAPK) and AP-1, HO-1 expression, and HO activity.	Thioctic Acid	104-107	heme oxygenase 1	Homo sapiens	187-191	
16631521-8	2006	These results suggest that ALA induces HO-1 expression through the production of ROS and subsequent activation of the p44/42 MAPK pathway and AP-1 in vascular smooth muscle cells.	Thioctic Acid	27-30	heme oxygenase 1	Homo sapiens	39-43	
16631521-9	2006	This study demonstrated that ALA increases the expression of HO-1, a critical cytoprotective molecule, and identified a novel pleiotropic effect of ALA on cardiovascular protection.	Thioctic Acid	29-32	heme oxygenase 1	Homo sapiens	61-65