PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16586042-0	2007	Tacrolimus and cyclosporine A inhibit human osteoclast formation via targeting the calcineurin-dependent NFAT pathway and an activation pathway for c-Jun or MITF in rheumatoid arthritis.	Tacrolimus	0-10	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	148-153	
16586042-6	2007	Addition of tacrolimus or cyclosporine A resulted in a decrease in the number of TRAP-positive multinucleated cells (TRAP+ MNCs) and a decrease in the extent of lacunar resorption pit formation as compared to the control cultures; thus, human monocyte-osteoclast differentiation was more effectively inhibited at the late stage and addition of tacrolimus or cyclosporine A resulted in a decrease in the mRNA expression of NFATc1, c-Jun, and MITF at the late stage.	Tacrolimus	12-22	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	430-435	
16586042-7	2007	Our results suggest that tacrolimus or cyclosporine A acts directly on human osteoclast precursors in RA patients and exerts their immunosuppressive effects on human monocyte-osteoclast formation via targeting both the calcineurin-dependent NFAT pathway and activation pathway for c-Jun or MITF.	Tacrolimus	25-35	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	281-286