PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16541750-3	2005	Since cyclosporine is a substrate and inhibitor of CYP3A4, researchers suspect that the immunosuppressant inhibits CYP3A4-mediated metabolism of statins, leading to an increase in statin plasma concentration and infrequently resulting in rhabdomyolysis.	Cyclosporine	6-18	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	51-57	
16541750-3	2005	Since cyclosporine is a substrate and inhibitor of CYP3A4, researchers suspect that the immunosuppressant inhibits CYP3A4-mediated metabolism of statins, leading to an increase in statin plasma concentration and infrequently resulting in rhabdomyolysis.	Cyclosporine	6-18	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	115-121	
16541750-8	2005	Furthermore, in the Japanese package inserts, it is either stated that cyclosporine inhibits CYP3A4-mediated metabolism or no comment is made on the mechanism.	Cyclosporine	71-83	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	93-99