PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16505095-2 2006 Emerging studies suggest that in addition to the nuclear localization of PELP1, it is predominantly localized in the cytoplasm in human breast tumors, leading to excessive nongenomic signaling and possibly to tamoxifen resistance. Tamoxifen 209-218 proline, glutamate and leucine rich protein 1 Homo sapiens 73-78 16505095-5 2006 We found that clones of MCF-7 human breast cancer cells overexpressing PELP1 in the cytoplasm were distinctly sensitive to TNF-alpha-induced apoptosis than were wild-type nuclear PELP1- and pcDNA vector-expressing clones as revealed by cell growth assay, cell cycle analysis, Annexin V staining, and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling assay. deoxyuridine triphosphate 347-351 proline, glutamate and leucine rich protein 1 Homo sapiens 71-76 16505095-5 2006 We found that clones of MCF-7 human breast cancer cells overexpressing PELP1 in the cytoplasm were distinctly sensitive to TNF-alpha-induced apoptosis than were wild-type nuclear PELP1- and pcDNA vector-expressing clones as revealed by cell growth assay, cell cycle analysis, Annexin V staining, and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling assay. deoxyuridine triphosphate 347-351 tumor necrosis factor Homo sapiens 123-132 16505095-7 2006 The mechanism behind TNF-induced apoptosis in these cells involves caspases, as revealed by poly(ADP-ribose) polymerase cleavage and the broad-spectrum caspase inhibitor Z-VAD-inhibited apoptosis. z-vad 170-175 tumor necrosis factor Homo sapiens 21-24