PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16339075-4	2006	We found that Brd4 was rapidly released from chromosomes upon treatment with antimicrotubule drugs, including the reversible agent nocodazole.	Nocodazole	131-141	bromodomain containing 4	Homo sapiens	14-18	
16339075-5	2006	Yet, when nocodazole was withdrawn, Brd4 was reloaded onto chromosomes, and cells proceeded to complete cell division.	Nocodazole	10-20	bromodomain containing 4	Homo sapiens	36-40	
16339075-7	2006	Consequently, Brd4+/- cells were impaired in their ability to recover from nocodazole-induced mitotic arrest: a large fraction of +/- cells failed to reach anaphase after drug withdrawal, and those that entered anaphase showed an increased frequency of abnormal chromosomal segregation.	Nocodazole	75-85	bromodomain containing 4	Homo sapiens	14-18	
16339075-8	2006	The reloading defect observed in Brd4+/- cells coincided with selective hypoacetylation of lysine residues on H3 and H4.	Lysine	91-97	bromodomain containing 4	Homo sapiens	33-37	
16339075-9	2006	The histone deacetylase inhibitor trichostatin A increased global histone acetylation and perturbed nocodazole-induced Brd4 unloading.	trichostatin A	34-48	bromodomain containing 4	Homo sapiens	119-123	
16339075-9	2006	The histone deacetylase inhibitor trichostatin A increased global histone acetylation and perturbed nocodazole-induced Brd4 unloading.	Nocodazole	100-110	bromodomain containing 4	Homo sapiens	119-123