PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16302093-0	2005	Curcumin induces human HT-29 colon adenocarcinoma cell apoptosis by activating p53 and regulating apoptosis-related protein expression.	Curcumin	0-8	tumor protein p53	Homo sapiens	79-82	
16302093-5	2005	The colon adenocarcinoma cells were treated with curcumin (0-75 microM) for 0-24 h. We observed that p53 was highly expressed in HT-29 cells and curcumin could up-regulate the serine phosphorylation of p53 in a time- and concentration-dependent manner.	Curcumin	49-57	tumor protein p53	Homo sapiens	101-104	
16302093-5	2005	The colon adenocarcinoma cells were treated with curcumin (0-75 microM) for 0-24 h. We observed that p53 was highly expressed in HT-29 cells and curcumin could up-regulate the serine phosphorylation of p53 in a time- and concentration-dependent manner.	Curcumin	49-57	tumor protein p53	Homo sapiens	202-205	
16302093-5	2005	The colon adenocarcinoma cells were treated with curcumin (0-75 microM) for 0-24 h. We observed that p53 was highly expressed in HT-29 cells and curcumin could up-regulate the serine phosphorylation of p53 in a time- and concentration-dependent manner.	Curcumin	145-153	tumor protein p53	Homo sapiens	101-104	
16302093-5	2005	The colon adenocarcinoma cells were treated with curcumin (0-75 microM) for 0-24 h. We observed that p53 was highly expressed in HT-29 cells and curcumin could up-regulate the serine phosphorylation of p53 in a time- and concentration-dependent manner.	Curcumin	145-153	tumor protein p53	Homo sapiens	202-205	
16302093-8	2005	These data suggest a possible underlying molecular mechanism whereby curcumin could induce the apoptosis signaling pathway in human HT-29 colon adenocarcinoma cells by p53 activation and by the regulation of apoptosis-related proteins.	Curcumin	69-77	tumor protein p53	Homo sapiens	168-171