PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16283513-0	2005	Essential role of PI-3K, ERKs and calcium signal pathways in nickel-induced VEGF expression.	Nickel	61-67	vascular endothelial growth factor A	Homo sapiens	76-80	
16283513-3	2005	Previous studies have revealed that nickel compounds can induce the expression of vascular endothelial growth factor (VEGF), which is a key mediator of angiogenesis both in physiological and pathologic conditions.	Nickel	36-42	vascular endothelial growth factor A	Homo sapiens	82-116	
16283513-3	2005	Previous studies have revealed that nickel compounds can induce the expression of vascular endothelial growth factor (VEGF), which is a key mediator of angiogenesis both in physiological and pathologic conditions.	Nickel	36-42	vascular endothelial growth factor A	Homo sapiens	118-122	
16283513-4	2005	In the present study, we investigated the potential roles of PI-3K, ERKs, p38 kinase and calcium signalling in VEGF induction by nickel in Cl 41 cells.	Nickel	129-135	vascular endothelial growth factor A	Homo sapiens	111-115	
16283513-5	2005	Exposure of Cl 41 cells to nickel compounds led to VEGF induction in both time- and dose-dependent manners.	Nickel	27-33	vascular endothelial growth factor A	Homo sapiens	51-55	
16283513-6	2005	Pre-treatment of Cl 41 cells with PI-3K inhibitor, wortmannin or Ly294002, resulted in a striking inhibition of VEGF induction by nickel compounds, implicating the role of PI-3K in the induction.	Nickel	130-136	vascular endothelial growth factor A	Homo sapiens	112-116	
16283513-9	2005	Pre-treatment of Cl 41 cells with intracellular calcium chelator, but not calcium channel blocker, inhibited VEGF induction by nickel.	Nickel	127-133	vascular endothelial growth factor A	Homo sapiens	109-113	
16283513-10	2005	Collectively these data demonstrate that PI-3K, ERKs and cytosolic calcium, but not p38 kinase, play essential roles in VEGF induction by nickel compounds.	Nickel	138-144	vascular endothelial growth factor A	Homo sapiens	120-124