PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16266470-0 2005 [Association of polymorphism in alpha-adducin gene with antihypertensive effect of Hydrochlorothiazide]. Hydrochlorothiazide 83-102 adducin 1 Homo sapiens 32-45 16266470-1 2005 OBJECTIVE: To explore the association between G614T single nuclear polymorphism (SNP) of the alpha-adducin gene and the antihypertensive effect of hydrochlorothiazide (HCTZ) in essential hypertensive (EH) patients. Hydrochlorothiazide 147-166 adducin 1 Homo sapiens 93-106 16266470-1 2005 OBJECTIVE: To explore the association between G614T single nuclear polymorphism (SNP) of the alpha-adducin gene and the antihypertensive effect of hydrochlorothiazide (HCTZ) in essential hypertensive (EH) patients. Hydrochlorothiazide 168-172 adducin 1 Homo sapiens 93-106 16266470-5 2005 RESULTS: After 6 weeks of HCTZ treatment, the decreases in DBP and MAP of patients carrying 614T allele of alpha-adducin were significantly greater than that of those carrying GG homozygotes (P < 0.05). Hydrochlorothiazide 26-30 adducin 1 Homo sapiens 107-120 16266470-9 2005 CONCLUSION: The present study suggests that the alpha-adducin G614T polymorphism is associated with the antihypertensive effect of HCTZ, which is more effective in patients with TT genotype. Hydrochlorothiazide 131-135 adducin 1 Homo sapiens 48-61