PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15692221-1 2005 BACKGROUND/AIMS: Water diuresis usually increases medullary oxygenation as a result of increased medullary synthesis of prostaglandins, but it is not clear whether this involves activation of cyclooxygenase-1 (COX-1) or cyclooxygenase-2 (COX-2). Water 17-22 mitochondrially encoded cytochrome c oxidase II Homo sapiens 238-243 15692221-8 2005 CONCLUSION: Renal medullary oxygenation is improved by water diuresis in normal young women in a way that is blocked by a selective inhibitor of COX-2 as well as non-selective cyclooxygenase inhibitors. Water 55-60 mitochondrially encoded cytochrome c oxidase II Homo sapiens 145-150