PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15674848-0 2004 TCDD causes suppression of growth and differentiation of MCF10A, human mammary epithelial cells by interfering with their insulin receptor signaling through c-Src kinase and ERK activation. Polychlorinated Dibenzodioxins 0-4 C-terminal Src kinase Homo sapiens 157-169 15674848-5 2004 To test the hypothesis that TCDD-induced c-Src kinase activation is casually related to this compound"s antagonistic action against insulin, we treated MCF10A cells with two c-Src blocking agents, an anti-Src antisense oligonucleotides blocker and a known specific inhibitor of c-Src kinase, PP-2 and studied the effect of insulin and TCDD on cell proliferation. Polychlorinated Dibenzodioxins 28-32 C-terminal Src kinase Homo sapiens 41-53 15674848-5 2004 To test the hypothesis that TCDD-induced c-Src kinase activation is casually related to this compound"s antagonistic action against insulin, we treated MCF10A cells with two c-Src blocking agents, an anti-Src antisense oligonucleotides blocker and a known specific inhibitor of c-Src kinase, PP-2 and studied the effect of insulin and TCDD on cell proliferation. Polychlorinated Dibenzodioxins 28-32 C-terminal Src kinase Homo sapiens 278-290