PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15674326-0	2005	Hematopoietic cytokines enhance Chk1-dependent G2/M checkpoint activation by etoposide through the Akt/GSK3 pathway to inhibit apoptosis.	Etoposide	77-86	AKT serine/threonine kinase 1	Homo sapiens	99-102	
15674326-6	2005	The G2/M arrest induced by etoposide was also enhanced or inhibited by expression of a constitutively activated or dominant-negative Akt mutant, respectively.	Etoposide	27-36	AKT serine/threonine kinase 1	Homo sapiens	133-136	
15674326-7	2005	Furthermore, SB216763 or LiCl, a specific inhibitor for the GSK3 kinase inhibited by Akt, enhanced the Chk1 phosphorylation and G2/M arrest by etoposide.	Etoposide	143-152	AKT serine/threonine kinase 1	Homo sapiens	85-88	
15674326-8	2005	These results indicate that hematopoietic cytokines protect etoposide-treated cells from DNA damage-induced apoptosis by promoting, through the PI3K/Akt/GSK3 signaling pathway, G2/M checkpoint that is dependent on Chk1-mediated inhibition of Cdc2.	Etoposide	60-69	AKT serine/threonine kinase 1	Homo sapiens	149-152