PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1551112-0 1992 Inhibition of p34cdc2 kinase activation, p34cdc2 tyrosine dephosphorylation, and mitotic progression in Chinese hamster ovary cells exposed to etoposide. Etoposide 143-152 cyclin dependent kinase 1 Homo sapiens 14-21 1551112-0 1992 Inhibition of p34cdc2 kinase activation, p34cdc2 tyrosine dephosphorylation, and mitotic progression in Chinese hamster ovary cells exposed to etoposide. Etoposide 143-152 cyclin dependent kinase 1 Homo sapiens 41-48 1551112-1 1992 p34cdc2 kinase, an enzyme essential for mitosis in mammalian cells, may play a role in etoposide-induced G2 phase arrest of Chinese hamster ovary cells. Etoposide 87-96 cyclin dependent kinase 1 Homo sapiens 0-7 1551112-2 1992 In this study, etoposide is shown to cause inhibition of a specific p34cdc2 kinase activation pathway, that of tyrosine dephosphorylation. Etoposide 15-24 cyclin dependent kinase 1 Homo sapiens 68-75 1551112-3 1992 Exposure of asynchronously dividing cells to etoposide caused a simultaneous rapid decline of both mitotic index and p34cdc2 kinase activity, suggesting that the kinase was not activated and that the arrest point was in late G2 phase. Etoposide 45-54 cyclin dependent kinase 1 Homo sapiens 117-124 1551112-6 1992 A 1-h exposure to etoposide during early G2 phase inhibited p34cdc2 kinase activation, its shift in electrophoretic mobility, and its tyrosine dephosphorylation, all of which correlated with a delay in mitotic progression. Etoposide 18-27 cyclin dependent kinase 1 Homo sapiens 60-67