PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15466214-3	2004	In AD LNCaP(nan) cells, dihydrotestosterone (DHT) stimulated in an androgen receptor (AR)-dependent way a phosphorylation signaling pathway involving steroid receptor coactivator (Src)-mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase (MEK)-1/2-ERK-1/2-cAMP-response element binding-protein (CREB).	Dihydrotestosterone	24-43	androgen receptor	Homo sapiens	67-84	
15466214-3	2004	In AD LNCaP(nan) cells, dihydrotestosterone (DHT) stimulated in an androgen receptor (AR)-dependent way a phosphorylation signaling pathway involving steroid receptor coactivator (Src)-mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase (MEK)-1/2-ERK-1/2-cAMP-response element binding-protein (CREB).	Dihydrotestosterone	24-43	androgen receptor	Homo sapiens	86-88	
15466214-3	2004	In AD LNCaP(nan) cells, dihydrotestosterone (DHT) stimulated in an androgen receptor (AR)-dependent way a phosphorylation signaling pathway involving steroid receptor coactivator (Src)-mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase (MEK)-1/2-ERK-1/2-cAMP-response element binding-protein (CREB).	Dihydrotestosterone	24-43	steroid receptor RNA activator 1	Homo sapiens	150-178	
15466214-3	2004	In AD LNCaP(nan) cells, dihydrotestosterone (DHT) stimulated in an androgen receptor (AR)-dependent way a phosphorylation signaling pathway involving steroid receptor coactivator (Src)-mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase (MEK)-1/2-ERK-1/2-cAMP-response element binding-protein (CREB).	Dihydrotestosterone	24-43	steroid receptor RNA activator 1	Homo sapiens	180-183	
15466214-3	2004	In AD LNCaP(nan) cells, dihydrotestosterone (DHT) stimulated in an androgen receptor (AR)-dependent way a phosphorylation signaling pathway involving steroid receptor coactivator (Src)-mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase (MEK)-1/2-ERK-1/2-cAMP-response element binding-protein (CREB).	Dihydrotestosterone	24-43	cAMP responsive element binding protein 1	Homo sapiens	319-323	
15466214-3	2004	In AD LNCaP(nan) cells, dihydrotestosterone (DHT) stimulated in an androgen receptor (AR)-dependent way a phosphorylation signaling pathway involving steroid receptor coactivator (Src)-mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase (MEK)-1/2-ERK-1/2-cAMP-response element binding-protein (CREB).	Dihydrotestosterone	45-48	androgen receptor	Homo sapiens	67-84	
15466214-3	2004	In AD LNCaP(nan) cells, dihydrotestosterone (DHT) stimulated in an androgen receptor (AR)-dependent way a phosphorylation signaling pathway involving steroid receptor coactivator (Src)-mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase (MEK)-1/2-ERK-1/2-cAMP-response element binding-protein (CREB).	Dihydrotestosterone	45-48	androgen receptor	Homo sapiens	86-88	
15466214-3	2004	In AD LNCaP(nan) cells, dihydrotestosterone (DHT) stimulated in an androgen receptor (AR)-dependent way a phosphorylation signaling pathway involving steroid receptor coactivator (Src)-mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase (MEK)-1/2-ERK-1/2-cAMP-response element binding-protein (CREB).	Dihydrotestosterone	45-48	steroid receptor RNA activator 1	Homo sapiens	150-178	
15466214-3	2004	In AD LNCaP(nan) cells, dihydrotestosterone (DHT) stimulated in an androgen receptor (AR)-dependent way a phosphorylation signaling pathway involving steroid receptor coactivator (Src)-mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase (MEK)-1/2-ERK-1/2-cAMP-response element binding-protein (CREB).	Dihydrotestosterone	45-48	steroid receptor RNA activator 1	Homo sapiens	180-183	
15466214-3	2004	In AD LNCaP(nan) cells, dihydrotestosterone (DHT) stimulated in an androgen receptor (AR)-dependent way a phosphorylation signaling pathway involving steroid receptor coactivator (Src)-mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase (MEK)-1/2-ERK-1/2-cAMP-response element binding-protein (CREB).	Dihydrotestosterone	45-48	cAMP responsive element binding protein 1	Homo sapiens	319-323	
15466214-3	2004	In AD LNCaP(nan) cells, dihydrotestosterone (DHT) stimulated in an androgen receptor (AR)-dependent way a phosphorylation signaling pathway involving steroid receptor coactivator (Src)-mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase (MEK)-1/2-ERK-1/2-cAMP-response element binding-protein (CREB).	Cyclic AMP	280-284	androgen receptor	Homo sapiens	67-84	
15466214-3	2004	In AD LNCaP(nan) cells, dihydrotestosterone (DHT) stimulated in an androgen receptor (AR)-dependent way a phosphorylation signaling pathway involving steroid receptor coactivator (Src)-mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase (MEK)-1/2-ERK-1/2-cAMP-response element binding-protein (CREB).	Cyclic AMP	280-284	androgen receptor	Homo sapiens	86-88	
15466214-3	2004	In AD LNCaP(nan) cells, dihydrotestosterone (DHT) stimulated in an androgen receptor (AR)-dependent way a phosphorylation signaling pathway involving steroid receptor coactivator (Src)-mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase (MEK)-1/2-ERK-1/2-cAMP-response element binding-protein (CREB).	Cyclic AMP	280-284	steroid receptor RNA activator 1	Homo sapiens	150-178	
15466214-3	2004	In AD LNCaP(nan) cells, dihydrotestosterone (DHT) stimulated in an androgen receptor (AR)-dependent way a phosphorylation signaling pathway involving steroid receptor coactivator (Src)-mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase (MEK)-1/2-ERK-1/2-cAMP-response element binding-protein (CREB).	Cyclic AMP	280-284	steroid receptor RNA activator 1	Homo sapiens	180-183	
15466214-5	2004	Use of dominant-negative forms of MEK-1/2 and CREB demonstrated in LNCaP(nan) cells that DHT induced [(3)H]thymidiine incorporation through a thus far unidentified molecule activated downstream of MEK-1/2, and antiapoptosis through phosphorylation of the transcription factor CREB.	Dihydrotestosterone	89-92	mitogen-activated protein kinase kinase 1	Homo sapiens	34-41	
15466214-5	2004	Use of dominant-negative forms of MEK-1/2 and CREB demonstrated in LNCaP(nan) cells that DHT induced [(3)H]thymidiine incorporation through a thus far unidentified molecule activated downstream of MEK-1/2, and antiapoptosis through phosphorylation of the transcription factor CREB.	Dihydrotestosterone	89-92	cAMP responsive element binding protein 1	Homo sapiens	46-50	
15466214-5	2004	Use of dominant-negative forms of MEK-1/2 and CREB demonstrated in LNCaP(nan) cells that DHT induced [(3)H]thymidiine incorporation through a thus far unidentified molecule activated downstream of MEK-1/2, and antiapoptosis through phosphorylation of the transcription factor CREB.	Dihydrotestosterone	89-92	mitogen-activated protein kinase kinase 1	Homo sapiens	197-204	
15466214-5	2004	Use of dominant-negative forms of MEK-1/2 and CREB demonstrated in LNCaP(nan) cells that DHT induced [(3)H]thymidiine incorporation through a thus far unidentified molecule activated downstream of MEK-1/2, and antiapoptosis through phosphorylation of the transcription factor CREB.	Dihydrotestosterone	89-92	cAMP responsive element binding protein 1	Homo sapiens	276-280	
15466214-9	2004	Interestingly, differences between the two cell lines were that in LNCaP-HP cells presence of an AI phenotype and lack of response to DHT were associated with constitutive activation of the protein kinase Src and interaction among Src, AR, and MNAR.	Dihydrotestosterone	134-137	steroid receptor RNA activator 1	Homo sapiens	205-208	
15466214-10	2004	In contrast, in LNCaP(nan) cells, presence of an AD phenotype and ability to respond to DHT were associated with DHT-dependent activation of Src kinase activity and interaction among Src, AR, and MNAR.	Dihydrotestosterone	88-91	steroid receptor RNA activator 1	Homo sapiens	141-144	
15466214-10	2004	In contrast, in LNCaP(nan) cells, presence of an AD phenotype and ability to respond to DHT were associated with DHT-dependent activation of Src kinase activity and interaction among Src, AR, and MNAR.	Dihydrotestosterone	88-91	steroid receptor RNA activator 1	Homo sapiens	183-186	
15466214-10	2004	In contrast, in LNCaP(nan) cells, presence of an AD phenotype and ability to respond to DHT were associated with DHT-dependent activation of Src kinase activity and interaction among Src, AR, and MNAR.	Dihydrotestosterone	88-91	androgen receptor	Homo sapiens	188-190	
15466214-10	2004	In contrast, in LNCaP(nan) cells, presence of an AD phenotype and ability to respond to DHT were associated with DHT-dependent activation of Src kinase activity and interaction among Src, AR, and MNAR.	Dihydrotestosterone	88-91	proline, glutamate and leucine rich protein 1	Homo sapiens	196-200	
15466214-10	2004	In contrast, in LNCaP(nan) cells, presence of an AD phenotype and ability to respond to DHT were associated with DHT-dependent activation of Src kinase activity and interaction among Src, AR, and MNAR.	Dihydrotestosterone	113-116	steroid receptor RNA activator 1	Homo sapiens	141-144	
15466214-10	2004	In contrast, in LNCaP(nan) cells, presence of an AD phenotype and ability to respond to DHT were associated with DHT-dependent activation of Src kinase activity and interaction among Src, AR, and MNAR.	Dihydrotestosterone	113-116	steroid receptor RNA activator 1	Homo sapiens	183-186	
15466214-10	2004	In contrast, in LNCaP(nan) cells, presence of an AD phenotype and ability to respond to DHT were associated with DHT-dependent activation of Src kinase activity and interaction among Src, AR, and MNAR.	Dihydrotestosterone	113-116	androgen receptor	Homo sapiens	188-190	
15466214-10	2004	In contrast, in LNCaP(nan) cells, presence of an AD phenotype and ability to respond to DHT were associated with DHT-dependent activation of Src kinase activity and interaction among Src, AR, and MNAR.	Dihydrotestosterone	113-116	proline, glutamate and leucine rich protein 1	Homo sapiens	196-200	
15466214-11	2004	Intriguingly, in LNCaP(nan) cells, we found that transcription through the prototypical CREB-responsive promoter c-fos could be induced in a DHT-dependent way, and this action was inhibited by the AR antagonist Casodex and MEK-1 inhibitor PD98059.	Dihydrotestosterone	141-144	cAMP responsive element binding protein 1	Homo sapiens	88-92	
15466214-11	2004	Intriguingly, in LNCaP(nan) cells, we found that transcription through the prototypical CREB-responsive promoter c-fos could be induced in a DHT-dependent way, and this action was inhibited by the AR antagonist Casodex and MEK-1 inhibitor PD98059.	Dihydrotestosterone	141-144	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	113-118	
15466214-11	2004	Intriguingly, in LNCaP(nan) cells, we found that transcription through the prototypical CREB-responsive promoter c-fos could be induced in a DHT-dependent way, and this action was inhibited by the AR antagonist Casodex and MEK-1 inhibitor PD98059.	Dihydrotestosterone	141-144	androgen receptor	Homo sapiens	197-199	
15466214-11	2004	Intriguingly, in LNCaP(nan) cells, we found that transcription through the prototypical CREB-responsive promoter c-fos could be induced in a DHT-dependent way, and this action was inhibited by the AR antagonist Casodex and MEK-1 inhibitor PD98059.	Dihydrotestosterone	141-144	mitogen-activated protein kinase kinase 1	Homo sapiens	223-228	
15466214-11	2004	Intriguingly, in LNCaP(nan) cells, we found that transcription through the prototypical CREB-responsive promoter c-fos could be induced in a DHT-dependent way, and this action was inhibited by the AR antagonist Casodex and MEK-1 inhibitor PD98059.	bicalutamide	211-218	cAMP responsive element binding protein 1	Homo sapiens	88-92	
15466214-11	2004	Intriguingly, in LNCaP(nan) cells, we found that transcription through the prototypical CREB-responsive promoter c-fos could be induced in a DHT-dependent way, and this action was inhibited by the AR antagonist Casodex and MEK-1 inhibitor PD98059.	bicalutamide	211-218	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	113-118	
15466214-11	2004	Intriguingly, in LNCaP(nan) cells, we found that transcription through the prototypical CREB-responsive promoter c-fos could be induced in a DHT-dependent way, and this action was inhibited by the AR antagonist Casodex and MEK-1 inhibitor PD98059.	bicalutamide	211-218	androgen receptor	Homo sapiens	197-199	
15466214-11	2004	Intriguingly, in LNCaP(nan) cells, we found that transcription through the prototypical CREB-responsive promoter c-fos could be induced in a DHT-dependent way, and this action was inhibited by the AR antagonist Casodex and MEK-1 inhibitor PD98059.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	239-246	cAMP responsive element binding protein 1	Homo sapiens	88-92	
15466214-11	2004	Intriguingly, in LNCaP(nan) cells, we found that transcription through the prototypical CREB-responsive promoter c-fos could be induced in a DHT-dependent way, and this action was inhibited by the AR antagonist Casodex and MEK-1 inhibitor PD98059.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	239-246	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	113-118	
15466214-11	2004	Intriguingly, in LNCaP(nan) cells, we found that transcription through the prototypical CREB-responsive promoter c-fos could be induced in a DHT-dependent way, and this action was inhibited by the AR antagonist Casodex and MEK-1 inhibitor PD98059.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	239-246	androgen receptor	Homo sapiens	197-199	
15466214-12	2004	In contrast, transcription through the PSA P/E promoter, a prototypical AR-dependent promoter directly activated by agonist, was obliterated only by Casodex.	bicalutamide	149-156	prosaposin	Homo sapiens	39-46	
15466214-12	2004	In contrast, transcription through the PSA P/E promoter, a prototypical AR-dependent promoter directly activated by agonist, was obliterated only by Casodex.	bicalutamide	149-156	androgen receptor	Homo sapiens	72-74	
15466214-15	2004	(2) Activation of the Src-MEK-1/2-ERK-1/2-CREB pathway is DHT dependent in AD LNCaP(nan) cells.	Dihydrotestosterone	58-61	steroid receptor RNA activator 1	Homo sapiens	22-25	
15466214-15	2004	(2) Activation of the Src-MEK-1/2-ERK-1/2-CREB pathway is DHT dependent in AD LNCaP(nan) cells.	Dihydrotestosterone	58-61	mitogen-activated protein kinase kinase 1	Homo sapiens	26-33	
15466214-15	2004	(2) Activation of the Src-MEK-1/2-ERK-1/2-CREB pathway is DHT dependent in AD LNCaP(nan) cells.	Dihydrotestosterone	58-61	cAMP responsive element binding protein 1	Homo sapiens	42-46	
15466214-16	2004	(3) DHT activation of this pathway is associated with induction of [(3)H]thymidine incorporation by a molecule activated downstream of MEK-1/2 and of antiapoptosis through activation of the transcription factor CREB in AD LNCaP(nan) cells.	Dihydrotestosterone	4-7	mitogen-activated protein kinase kinase 1	Homo sapiens	135-142	
15466214-16	2004	(3) DHT activation of this pathway is associated with induction of [(3)H]thymidine incorporation by a molecule activated downstream of MEK-1/2 and of antiapoptosis through activation of the transcription factor CREB in AD LNCaP(nan) cells.	Dihydrotestosterone	4-7	cAMP responsive element binding protein 1	Homo sapiens	211-215