PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15155554-6 2004 The inhibition type of ticlopidine was found to be mixed type, with a component of mechanism-based inhibition, whereas thioTEPA inhibited CYP2B6 in a competitive manner. Thiotepa 119-127 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 138-144 15155554-8 2004 For thioTEPA the next sensitive P450 activity after CYP2B6 was coumarin 7-hydroxylation (IC(50), 256 microM). Thiotepa 4-12 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 52-58 15155554-10 2004 Thus, thioTEPA is a drug of choice when high CYP2B6 selectivity among major P450 enzymes is required. Thiotepa 6-14 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 45-51