PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15082752-1	2004	The present study documents a role for brain-derived tumor necrosis factor-alpha (TNF) in the mechanism of action of the antidepressant drug desmethylimipramine (desipramine).	Desipramine	141-160	tumor necrosis factor	Rattus norvegicus	82-85	
15082752-1	2004	The present study documents a role for brain-derived tumor necrosis factor-alpha (TNF) in the mechanism of action of the antidepressant drug desmethylimipramine (desipramine).	Desipramine	162-173	tumor necrosis factor	Rattus norvegicus	82-85	
15082752-3	2004	Chronic desipramine administration transforms TNF-mediated inhibition of NE release to facilitation, dependent upon alpha2-adrenergic receptor activation.	Desipramine	8-19	tumor necrosis factor	Rattus norvegicus	46-49	
15082752-6	2004	To determine whether this transformation is due to desipramine-induced inhibition of TNF bioactivity in the brain, rats were i.c.v.	Desipramine	51-62	tumor necrosis factor	Rattus norvegicus	85-88	
15082752-10	2004	Although simultaneous microinfusion of rrTNF with chronic desipramine administration prevents the transformation induced by desipramine, microinfusion of rrTNF enhances TNF inhibition of NE release.	Desipramine	124-135	tumor necrosis factor	Rattus norvegicus	41-44	
15082752-17	2004	microinfusion of rrTNF with concomitant desipramine administration opposes decreases in neuron-associated TNF levels, required to transform presynaptic sensitivity to TNF, which is necessary for the drug to be efficacious.	Desipramine	40-51	tumor necrosis factor	Rattus norvegicus	106-109