PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15020199-5 2004 In search for novel markers of skin tumor promotion, we found that TPA application to mouse skin resulted, as an early event, in an increased expression of phosphatidyinositol 3-kinase (PI3K), phosphorylation of Akt at threonine308 and activation of nuclear factor kappa B (NF-kappaB). Tetradecanoylphorbol Acetate 67-70 thymoma viral proto-oncogene 1 Mus musculus 212-215 15020199-6 2004 Topical application of oleandrin before TPA application to mouse skin resulted in significant reduction in TPA-induced expression of PI3K and phosphorylation of Akt, and inhibition of NF-kappaB activation. Tetradecanoylphorbol Acetate 107-110 thymoma viral proto-oncogene 1 Mus musculus 161-164